تأثیر تمرین هوازی بر میزان بیان mir126 عضله قلبی در رت‌های دیابتی

Background: Aerobic training is well supported as a useful component of an exercise. One of the most common adaptations that occur in this type of training is creating new vessels and increased angiogenesis factors. Aerobic training can be effective on angiogenesis.The aim of this study was to investigate the effect of aerobic training on cardiac expression of mir-126 in normal and diabetic rats. Methods: 35 Rats divided to two categories, diabetic and non-diabetics rats. Then each category of diabetic and non diabetic animals divided to two groups: under training and nontraining.Cardiac muscle was removed and immediately placed into liquid nitrogen. Cardiac expression of mir-126 investigated in rat cardiac muscle using Real-time PCR. For data analysis, One-way ANOVA and post-hoc Tukey’s test were used. Results: The study results showed diabetes significantly decreases cardiac expression of mir126 and 8 weeks of aerobic training significantly increases cardiac expression of mir126 in healthy and diabetic rats. Conclusion: It seems aerobic training can prevent negative effects of diabetes via angiogenic path. Thus, kindle regulatory rocesses by mir126 that via aerobic training are impressed, could be worthy strategy on development of new theraphy methods in diabetes treatment.